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RK-33 has shown potent activity in preclinical cancer models.
Further, PA-AgNPs has shown potent antibacterial effect on E. coli cells.
Although bilirubin has shown potent anti-oxidative and anti-inflammatory functions, its clinical applications have been limited due to its insolubility and short half-life.
We have identified inhibitor 4f which has shown potent enzyme inhibitory (Ki = 13 nM) and cellular (IC50 = 21 nM in neuroblastoma cells) assays.
Out of these seven compounds has shown potent inhibitory activity against p38 MAP kinase with IC50 values ranging from 12.97 to 223.5 nM.
Ponatinib has shown potent activity against chronic myeloid leukaemia that is resistant to available treatment, although it is associated with arterial occlusion.
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Specifically, 2,4,5,6-tetrasubstituted dihydropyrimidines have shown potent antimycobacterial activity.
Compounds (189, 5, 190) had shown potent anti-trypanosomal activity against Trypanosoma brucei brucei (IC50 0.032, 0.032, 1.33 µM).
Twelve of the 20 newly synthesized 4- substituted benzopyrones have shown potent antihistaminic H1 activity.
The hepatitis C virus (HCV) NS4B inhibitors have shown potent inhibition of HCV replication in vitro.
Previous phytochemical studies have shown potent antioxidant, free radical scavenging, antimutagenic and antigenotoxic activities of flavonoids and phenol isolated from Rhamnus alaternus roots and leaves.
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