Also, the anatomical/mechanical hypothesis has shown merit in explaining metastatic patterns, and can be presumed to be important in CUP.
The most widely used marker, CA125, has shown merit in pilot screening studies and ovarian cancer management, but the sensitivity for early-stage disease before clinical detection remains questionable (Bast et al, 1998).
The use of antioxidants, particular those which activate the transcription factor NRF2, alongside chemotherapy has shown merit in this regard in experimental models (Wang et al, 2000; Robinson et al, 2013).
The Rapid Rural Appraisal technique and informal diagnostic surveys have shown merit in generating valuable farm level data relevant for project design.
The pressure vessel of a combination of the outer shell of CFRP for strength element at a cryogenic temperature and the inner liner of aluminum for gas barrier has shown excellent weight merit for this purpose.
When this method is not possible (i.e. due to incomplete growth charts), it becomes important to then use an alternative method (e.g. the 50th percentile BMI method) that has shown some clinical merit.
One option that has been scientifically studied and has shown to have some merit, is the use of diluted vinegar.
"The fact is that everything we produced so far has shown that this was a merit-based decision by career staffers at the Department of Energy," the official said.
While there have been several clinical trials of combined therapy none has shown positive enough effects to merit the consideration as a viable treatment for MS. Finally, regarding neuroprotective and specially regenerative treatments, such as stem cell therapy, while their research is considered of high importance at the moment they are only a promise of future therapeutic approaches.
In cases involving copyright claims, where a copyright holder has shown likelihood of success on the merits of a copyright infringement claim, the Ninth Circuit has held that irreparable harm is presumed.
