A few animal and human studies have shown efficacious bone regeneration and healing with functional restoration after the implantation of rhBMP2 [ 10– 13].
Genome wide gene expression profiling after miRNA perturbation, combined with sequence conservation analysis, has shown that efficacious miRNA-target pairing is mediated through perfect pairing of the seed region [ 12, 16, 17].
Of note, the opioid antagonist nalmefene has shown to be efficacious in preliminary findings with better tolerability than naltrexone [ 104].
In both, the in vitro and in vivo studies, the hydro-alcoholic extract has shown to be more efficacious than the aqueous extract.
Previous research has shown this intervention to be efficacious in reducing OCD symptoms and comorbidities in patients.
Systematic review has shown that Olanzapine is more efficacious than other second generation antipsychotic drugs [ 40].
Due to the fact that also "IRENA" has not been evaluated yet, we included another comparison treatment that has been shown efficacious already [ 68- 70].
In addition, lithium has been shown efficacious in augmenting response in antidepressant non-responders and in severe treatment-resistant unipolar major depression (Haussmann and Bauer 2013).
The methodology has been shown efficacious in determining the solubility parameters of oils even in those oils with low content of asphaltenes and a high amount of particles in suspension, where other methods had not yielded a good performance.
With two recent systematic reviews and meta-analyses on the efficacy of lithium compared to placebo and other treatment options, it can now be concluded that lithium is the only drug that has been shown efficacious in the prevention of any mood episodes, manic episodes and depressive episodes in randomised trials not enriched for prior response to and tolerance of lithium.
Furthermore, the use of ketamine to treat CPSP has been shown efficacious in CPSP patients [ 30, 31].
