Previously, researchers have shown that individuals who no longer meet the criteria still have severe deficits in several areas when compared to atypically developing controls.
The resulting Hdac3 conditional knockout (CKO) mice were runted and had severe deficits in intramembranous and endochondral bone formation.
However, all of these definitions (summarized in Table 1) have severe deficits.
Overall, 75% recovered or had mild deficits, while 18% had severe deficits, with 7% dying as a result of the encephalitis [ 22].
Tc1 mice have been previously shown to have severe deficits in motor skills in different motor coordination tasks such as the rotarod, static rod and footprint tests [19].
The mice had severe deficits in learning and memory, developed motor deficits earlier than α-synuclein single-transgenic mice, and showed prominent age-dependent degeneration of cholinergic neurons and presynaptic terminals.
Nikendei et al. in their study observed that final year students had severe deficits in their ward round skills, with the deficits predominantly in focused physical examination, chart reviewing, prescriptions and documentation [ 17, 18].
The data from the current study go against the former explanation: although the dyslexics in this study had poor reading ability relative to the non-dyslexic group, they did not have severe deficits.
Thus, despite the administration of HAART, children with HIV who presented with neuroimaging abnormalities were observed to have severe deficits in cognitive function as compared to non-infected children.
Of note, NCED mutants have been identified in Zea mays (vp14) (Schwartz et al. 1997), A. thaliana (nced3) (Iuchi et al. 2001; Ruggiero et al. 2004; Huang et al. 2008) and S. lycopersicon (notabilis) (Burbidge et al. 1999) and all have severe deficits in ABA, particularly under water stress.
