Uncapped sectors like agriculture may have sequestration potential, perhaps through manure management at dairies or biochar.
In Malawi 75% of cases coming to autopsy have sequestration with associated perivascular haemorrhages and intravascular microthrombi, wheras 25% have sequestration but no haemorrhages or other perivascular pathology visible on routine haematoxylin and eosin-stained sections (Dorovini-Zis et al., 2011).
Although the clinical manifestations of these 3 children were indistinguishable from those of children with cerebral malaria, histologic examination showed that none of these 3 patients had sequestration of parasitized erythrocytes in cerebral tissue (the pathologic hallmark of cerebral malaria).
We examined the brains of 50 Malawian children who satisfied the clinical definition of cerebral malaria (CM) during life; 37 children had sequestration of infected red blood cells (iRBCs) and no other cause of death, and 13 had a nonmalarial cause of death with no cerebral sequestration.
Sequestration is thought to be most severe in capillaries and postcapillary venules although only one study, in adults, has compared sequestration between vessel types (MacPherson et al., 1985).
Jonathan Dordick has seen sequestration, the 5% across-the-board spending cut imposed earlier this year on every federal agency, as both a scientist and a university administrator.
One land use that is particularly amenable to this type of manipulation is agricultural land, which often has high sequestration potential.
If large changes in the Raf-1-P amplitudes are observed for perturbations in the MKP-3 concentrations, one can infer that the system has weak sequestration.
Despite 6 hours of liberal fluid loading in PRISM, 91% of patients still had visible sequestration and in 35% the degree of sequestration was unchanged or had increased.
They've allowed sequestration – and its devastating effect on communities across the country – to continue.
