Interestingly, CTCF, a predicted target of miR-542-3p, is down-regulated in pilocytic astrocytoma, and a recent investigation into the higher-order chromatin structure of the INK4/ARF locus in senescent cells, has revealed down-regulation of CTCF in oncogene-induced senescent cells [ 20].
Our previous studies have revealed down-regulation of PER2 in HCC [ 18], CML [ 19, 20], HNSCC [ 21], and breast cancer [ 25] but not in endometrial cancer [ 26].
Additionally the same study has revealed that down-regulation of SPRR in axotomized neurons impaired directed axonal outgrowth [28].
In contrast, previous study has revealed that down-regulation of the ZmPP2Ca transcript was observed in drought tolerant lines, whereas transcript levels were up-regulated in sensitive lines under drought stress [ 17].
In spite of HMGCR increase in TPS-induced AL, the lathosterol oxidase gene has been found previously to be down-regulated in intracellular amastigotes ([ 28] and unpublished custom data) and the analysis reported in this study has revealed that the down-regulation of this gene is due to the specific influence of TPS and TS.
Interestingly, examining the bacterial transcriptomic response "in the context" of the other biotic stress responses as done in this study, has revealed that the down-regulation of genes encoding photorespiration functions, metalloproteases, sugar transport and sucrose/starch degradation (major CHO metabolism) are seen more specifically in response to bacterial infection.
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