Although Chief Justice John Marshall acknowledged that Indian nations had a certain amount of sovereignty, the exact extent of such sovereignty as well as the place of tribes within the federal system has remained ill-defined.
Big data has emerged as a big trend over the last several years, but as an area it has remained ill-defined and focused for the most part on data scientists, while ignoring business users.
How the various components of the CMG engage nucleic acid strands during this process has remained ill-defined.
The relationship between autophagy and microbes, indeed, has remained ill-defined until a recent convergence of studies showing that autophagy is an innate immune defense against bacteria, protozoa, and viral pathogens [ 64].
Although many studies have reported that MDs are associated with oxidative stress in both animal models and in patients [13,48], the sources of ROS and their involvement remained ill defined.
Abish's mother was thoroughly assimilated and had "sought, if not to disassociate, then to distance herself from the Jewish ceremonies," while the father's attempt to communicate their Jewishness to his son remained "ill defined" and "perplexing".
Evidence suggests clearly that genistein has pleitropic effects on cancer cells, but the critical mechanisms of action remain ill defined.
For glomerulonephritis, MMP inhibition has exhibited promising results in rat anti-Thy 1.1 nephritis [ 63], but several key parameters in such a strategy remain ill defined, including the target MMP s), timing and duration of intervention, specificity, dosage and delivery system.
Although DNA sequence information from tumors has revealed a number of frequently occurring mutations, affecting well-known tumor suppressor genes and proto-oncogenes, many of the driver mutations remain ill defined.
Hypoglycaemia has been associated with increased cardiovascular (CV) risk and mortality in a number of recent multicentre trials, but the mechanistic links driving this association remain ill defined.
