HR has relevant roles in DNA repair, chromosome segregation and generation of genetic variation.
Cav-1 has relevant roles in cell polarization and in directional migration and they are in part due to its differential localization in the cell [ 25, 30, 47].
The figures reached by depot neuroleptics show that these drugs have relevant role to play.
EVG had relevant role in the design and implementation of the study and JPC had substantial contribution in the interpretation of data and its critical evaluation.
Other F-box proteins included in our analysis might have relevant roles as well, but their functional roles in ovarian cancer cell lines remain unexplored.
The coagulation factors are potentially correlated to the inflammatory-related peptides present in FF and have relevant roles within the follicle [ 35, 36].
Three other hubs are ZFP112, a gene coding for an unknown zinc-finger protein, and SHC4 and TMEM123, both having relevant roles in neuronal homeostasis.
Although oxidative stress and proinflammatory cytokines have relevant roles in NASH pathogenesis, our understanding of the molecular mechanisms involved in liver cell injury contributing to progression from NAS to NASH is still very limited.
As recently reviewed (Orso et al, 2008), AP-2 proteins have relevant roles in tumorigenesis by regulating some key genes involved in cell proliferation (ErbB-2, c-myc proto-oncogenes), cell cycle regulation (CDKN1A), cell adhesion and invasion (MMP-2, MMP-9, PAR-1 and MUC18).
Another case worth to be mentioned is the Australian Wine Research Institute, that has actively promoted research in the field of wine in general and has had a relevant role in spreading a sustainable culture among wineries.
