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The Ubx-YFP line has reduced viability; 31% of homozygotes survive to adulthood.
Although we observe no obvious phenotype of the helicase mutant alone, the pcn1-K164R rad8-HD double mutant has reduced viability in response to MMS compared with pcn1-K164R rad8∆.
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These data show that r2d21 mutants have reduced viability and defective female fertility that stems from abnormal follicle cell function, and Dicer-1 impacts this process.
Null mmp1 mutants had reduced viability during larval development compared with controls (w : 60%; mmp1: 17%).
Crtap KO mice had reduced viability with low BMD and microCT parameters.
Using a FACS-based live/dead discrimination assay, we determined that cells maintained in 2i/L/SB590885 had reduced viability.
Compared to Jurkat T cells, U937 cells had reduced viability in vitro as measured by trypan blue dye exclusion.
Hoc-7 cells are known to express functional progesterone receptor and have reduced viability in response to progesterone receptor agonists.
Namgung and Xia (2001) have shown that primary cultures of rat cerebellar neurons exposed to 5 15 μM sodium arsenite and 1 5 mM DMA V) had reduced viability.
This suggests that blt/ blt mature SP thymocytes have reduced viability, at least in vitro, which is likely to contribute to the defect in vivo.
Since fruΔ C mutant males have reduced viability ([ 7]; Figure S2A), we conclude that only common FruB and FruC isoforms play essential developmental roles in both sexes.
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