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"Nature has provided a system in which regulatory cells become increasingly potent but carry with them the seeds of their destruction," says Strom. "Overall, they did a fine job," says transplant immunologist Thomas Wekerle of the Medical University of Vienna, who wasn't involved with the research.
The formation of NHREC has provided a system for the regulation, capacity building and coordination of activities of various institutional review boards.
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Most recently, the knock-in models have provided a system with pathophysiological levels of JAK2V617F and have permitted higher-resolution studies of particular cell compartments (e.g. stem and progenitor cells).
These have provided a system to test the function of PfAMA1 by inserting specific mutations and through this added additional evidence that this protein is required for merozoite invasion (Leykauf et al., 2010).
Taken together, through comparative transcriptome analysis and construction of a citrus gene coexpression analysis, we have provided a systems view of citrus response to the Ca. Liberibacter infection causing HLB.
The recent discovery of H-NOX domains has provided a model system to investigate the role of porphyrin π-stacking within a heme protein scaffold.
The European corn borer (ECB), Ostrinia nubilalis (Hubner), has provided a model system to study the evolution of sex pheromones among closely related races and species.
The nematode Caenorhabditis elegans has provided a powerful system for dissecting the genetic mechanisms controlling animals' intrinsic biology and interaction with environmental factors.
Drosophila has provided a valuable system in which to investigate RPTP function, because its genome encodes only six RPTPs, and three of these (Lar, Ptp69D, Ptp52F) have single-gene loss-of-function (LOF) phenotypes affecting axon guidance and synaptogenesis (reviewed by Johnson and Van Vactor, 2003).
Drosophila has provided a powerful genetic system in which to elucidate fundamental cellular pathways in the context of a developing and functioning nervous system.
Selection for exercise-adapted phenotypes in the Thoroughbred racehorse has provided a valuable model system to understand molecular responses to exercise in skeletal muscle.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com