Sentence examples for has proven active from inspiring English sources

Stress-assisted grain boundary migration is a mechanism that has proven active in polycrystals but that relies on a limited number of models.

PABA/NO has proven active in several cancer models in vitro and in vivo, but its tendency to be metabolized via a variety of pathways, some that generate inactive metabolites and hydrolysis products, limits its potential as a drug.

The RKI has recently used the phrase "limited virucidal activity" ("active against enveloped viruses such as HIV, HBV, and HCV") to describe a preparation that has proven active against two representative enveloped viruses, vaccinia virus and bovine viral diarrhea virus (BVDV) [ 11].

Similarly, the results of this study should not be generalized to different subpopulations of breast cancer patients; weekly docetaxel has proven active and extremely well tolerated among elderly breast cancer patients, a population that would be at risk of toxicity with standard 3-weekly scheduling [ 30, 31].

The Bombyx mori actin 3C promoter and Drosophila ubiquitin promoter have proven active in a variety of insect species [ 13] and should be evaluated in Spodoptera insect cell culture as an alternative means to possibly improve transgene expression.

It is interesting to note that our reporter assays have not demonstrated promoter activity of the Juan-A 5'UTR in cell lines from three mosquito species, while 5'UTRs of mosquito non-LTRs from 3 non-LTR clades have proven active in all 3 lines (not shown).

Isotretinoin (13- cis -retinoic acid, 13cRA) has proven to be active in chemoprevention of head and neck squamous cell carcinoma (HNSCC).

Cetuximab (Erbitux, Merck, Lyon, France), a monoclonal antibody interfering with the extracellular domain of EGFR, has proven to be active in EGFR expressing CRC in whom other treatments have failed (Jonker et al, 2007).

Trastuzumab is a humanised monoclonal antibody that binds to the domain IV of the extracellular segment of HER2 and has proven to be active in HER2-overexpressing breast tumours; the advantage of adding the monoclonal antibody to standard systemic treatments has been demonstrated in a meta analysis with consistent improvement in overall survival and progression-free survival (Harris et al, 2011).

Fotemustine, a cytotoxic alkylating agent belonging to the nitrosureas family, recently used in an alternative condition regimen (fotemustine plus etoposide, cytarabine, and melphalan) for lymphoma patients 4, has proven to be active when used as single agent in the MM relapsing setting.

In fact, previous reports have already demonstrated the low activity of this drug against C. neoformans isolates, even though it has proven to be more active in vivo [ 19].