Even in pre-clinical research models, extreme hemodilution by blood replacement with synthetic, acellular crystalloid/colloid solutions has proved efficacious for avoiding ischemia/reperfusion in vivo after several hours of circulatory arrest under ultraprofound hypothermia (<10 °C).
Even in pre-clinical research models, extreme hemodilution by blood replacement with synthetic, acellular crystalloid/colloid solutions has proved efficacious for avoiding ischemia/reperfusion in vivo after several hours of circulatory arrest under ultraprofound hypothermia (<10 °C) [1,2].
BG control is, therefore, mandatory and has proved efficacious in improving neurological outcome in stroke [ 14].
Interestingly, an immunotherapeutic approach that targets CD22, epratuzumab, has proved efficacious in the treatment of non-Hodgkin lymphoma, and in the autoimmune diseases, systemic lupus erythematosus and primary Sjögren's syndrome [ 30].
It has separate access for junior students, senior students and teachers, contains various interactive sections, ranging from disease fact-sheets to games and quizzes, and has proved efficacious in improving students' knowledge.
Physiotherapy consisted of a combined therapy approach that has proved efficacious in patellofemoral pain syndrome 19 and included patellar mobilisation, patellar taping, a progressive programme of vasti muscle retraining exercises with electromyographic biofeedback, hamstring and anterior hip stretches, hip external rotator retraining, and a home exercise programme.
Although systemic MSC administration has proven efficacious and has a large advantage as our above previous studies [11, 12], possible risks, including pulmonary embolism, pose a serious issue [13, 14].
This has proven efficacious in preclinical models [48], and will be tested clinically by Merck and Astrazeneca in the near future (NCT01021748: MK2206 and AZD6244 for solid tumors).
ACT has proven efficacious at promoting and maintaining life-style changes and improving quality of life.
B-cell depletion with the anti-CD20 antibody RTX has proven efficacious in RA [ 7, 8, 30].
Despite its well-known teratogenic effects, it has proven efficacious in treating a wide variety of conditions including multiple myeloma.
