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Replacement of the phenol subunit with a bioisostere has proved achievable; this substituent could be further optimised.[ 12] Most compounds were not sufficiently potent against the enzyme to give significant activity in the parasite assays.
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Health has proved trickier.
That has proved wrong.
This has proved hard.
That has proved inadequate.
He has proved that.
It has proved useful.
So it has proved.
This has proved invaluable.
Although research has proven that early-strength is achievable, there exist limited published durability data for these systems.
"Austin today has proven that ending veteran homelessness isn't just aspirational – it's achievable".
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