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This complex has proteolytic activity and is known to cleave several type I transmembrane proteins including Notch and APP.
To characterize the nature of the protective role of TTR on A-Beta toxicity and since TTR has proteolytic activity [16], we hypothesized that TTR could cleave A-Beta and thus, contribute to its clearance.
Thus, Heliconius (including Laparus), a group of nymphalid Lepidoptera, produce saliva that has proteolytic activity [10], [24], and light microscopy has revealed that pollen grains exposed to the saliva for >200 min had modified "exines," which has been attributed to proteolysis [25].
Thus we conclude that TldD has proteolytic activity.
These results indicate that ddTpp1 has proteolytic activity similar to that of human TPP1.
It has proteolytic activity at 37°C in a broad pH range, similar to the conditions found during infection in women and men [ 7, 34, 52, 57].
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It is relevant to mention that the recombinant protein TvLEGU-1r obtained in this study did not have proteolytic activity and could not be activated (data not shown) for biochemical and direct functional assays, using the same reported conditions [ 58].
A protease assay, conducted to confirm their functionality, indicated that both recombinant proteins had proteolytic activity.
Indeed, this approach would be particularly interesting for calpain kinetoplastids since it is speculated that most calpain-like proteins do not have proteolytic activity, since the amino acid residues essential for catalytic activity are altered [14].
These results demonstrate that the recombinant Sl3-MMPm had proteolytic activity on MBP.
ADAM-12, a disintegrin metalloproteinase, is also known to have proteolytic activity against IGFBP-3 [ 77].
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