Tyrosine kinase inhibitors (TKIs), e.g. sunitinib and sorafenib, and monoclonal antibodies, e.g. bevacizumab with IFNα, have produced improvements in terms of progression free survival (PFS) and overall survival (OS).
Some charter schools have proven successful and the much-touted KIPP programme has produced marked improvement in test scores for low-income children.
The research and development in this technology, all over the world, has produced tremendous improvement in device characteristics, especially long-term reliability.
Modern technology has produced substantial improvements in equipment and materials, and it has lowered final costs.
Over the last 40 years, a series of large trials conducted by the Gynecologic Oncology Group and other cooperative groups has produced striking improvements in patient outcome; but the majority still dies of their disease.
While patients with poor risk features have a more guarded outcome, treatment with temsirolimus has produced meaningful improvements in overall survival for this population.
Although the use of IMRT has produced significant improvements in LRRFS, effective treatment of distant metastases remains an important problem to be solved.
The average 10% economic growth a year for the past three decades has produced dramatic improvements in the living standards of Chinese citizens.
Although an aggressive and intensive multimodality approach (surgery, cytotoxic chemotherapy, radio-metabolic treatment) has produced some improvements in the overall cure rate of these patients, the treatment strategies are still far from satisfaction [ 1, 2].
