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Our data also builds on previously published evidence that Ad5WT has potent anticancer efficacy [29], even at low doses.
For example, the glucosinolate glucoraphanin (4-methylsulfinylbutyl) has potent anticancer activity [ 37, 41].
Recent studies have shown that curcumin, either alone or in combination with other anticancer agents, has potent anticancer effects [ 1].
Taken together, these data showed that the DNA/HDAC dual-targeting drug CY has potent anticancer activity in vivo.
Curcumin is a well-known chemopreventive agent that has potent anticancer activity in a wide variety of tumor cells [ 10, 11].
We have shown that S. crispus has potent anticancer activities in vitro and could therefore, potentially be a source for a pharmacologically active product suitable for development as a chemotherapeutic agent.
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Recently, our research group identified 1,8-Cineole, as one of the predominant compound present in the hexane extract (HE-C), whose leaves have potent anticancer activity.
The results demonstrated that some compounds had potent anticancer activity against four tumor cell lines, and showed good selectivity on tumor cells over somatic cells.
Evaluation of the anticancer activity of these agents using seven cancer cell lines and two healthy cell lines found that several derivatives had potent anticancer activity and excellent selectivity indexes toward cancer cells.
In addition, entrainment of Arabidopsis plants and postharvest cabbage causes cyclical accumulation of metabolites that function in plant defense; in edible crops, these metabolites also have potent anticancer properties [5].
This is perhaps unsurprising given that Ad5WT has been shown to have potent anticancer activity [29].
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