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Benznidazole is the only drug approved for treatment during the acute and asymptomatic chronic phases of Chagas disease; however, it has poor efficacy during the symptomatic chronic phase.
It is well known that chemical agriculture pesticides tend to accumulate in soil causing poisoning, gather in plants and crops, have toxic effect on ecology and sometimes has poor efficacy against some types of microorganisms.
Mitomycin C diffuses mainly into the mucosa but poorly deeper into lamina propria during intravesical therapy, and this may explain why MMC has poor efficacy treating tumors growing deeper in the bladder wall than Ta tumors.
Chemotherapy in metastatic EC has poor efficacy and has not been validated through large randomized trials; moreover, there is no data reported in the literature on chemotherapy tolerance and efficacy in elderly patients with EC.
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Commercial disinfectants as well as H2O2 were found to have poor efficacy (log reduction around 2 CFU/gm) against internalized Salmonella.
Commercial disinfectants (anshin-yasai and yokosan) as well as H2O2 are found to have poor efficacy (log reduction around 2 CFU/gm).
The currently available iron chelators have poor efficacy in depleting the macrophage iron stores and, therefore, have a poor impact on the infection.
This drug combination has also been previously reported to have poor efficacy (70% Adequate Clinical and Parasitological Response at day 28 PCR corrected [1]).
In metastatic disease, currently used radiotherapeutic and chemotherapeutic regimens have poor efficacy and treatment resistant disease progression leads to death within few months [3].
Cyclosporine therapy appears to have poor efficacy in Shiba dogs with CE.
Conventional therapies for the treatment of CRPS-1 with dystonia have poor efficacy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com