Although L. major is pteridine- and purine-auxotroph, well-established folate biosynthesis inhibitors, such as methotrexate, have poor effect over the parasite survival.
the number of attacks per month exceeds two; attack medications have poor effect; the patient's quality of life is reduced considerably due to the migraine; frequent or very long-lasting cases of aura occur.
Prophylactic treatment should be considered [10] if the number of attacks per month exceeds two; attack medications have poor effect; the patient's quality of life is reduced considerably due to the migraine; frequent or very long-lasting cases of aura occur.
The thermal diffusivity and electrical conductivity of the BN matrix have been measured and showed that carbon fibers have poor effects on the intrinsic properties of BN.
We found that increased levels of LDH had poor effects on both overall survival and distant metastasis-free survival (P = 0.009 and 0.035, respectively), and increased pretreatment level of serum ALP had poor effects on both overall survival and local recurrence-free survival (P = 0.037 and 0.039, respectively).
If the effect size is moderate, more conclusions are possible: either the effect is moderate and the outcome measure is responsive, or the effect is large or small and the outcome measure has poor responsiveness because the true effect is over- of underestimated by the instrument.
However, orlistat frequently leads to gastrointestinal adverse effects, has poor long-term persistence rates, and is rarely used [ 15].
In the dynamic study, the tumor became ambiguous due to the influence of the biliary drainage, and it had poor contrast effect in any contrast phase (Fig. 2d).
d Dynamic liver magnetic resonance imaging showed that the tumor became ambiguous due to the influence of the biliary drainage, and it had poor contrast effect in all contrast phases (the displayed image is early phase image).
Short-acting barbiturates are commonly given intravenously; they have poor analgesic effects yet reasonable muscle relaxation.
