Sentence examples for has originally been identified from inspiring English sources

In contrast, LEDGF/p75 has originally been identified in a cellular complex with multimeric IN32 and the protein is known to modulate the dynamic structure of HIV-1 IN by stabilizing subunit-subunit interactions63.

While aslA, ibeB, yijP and ompA have homologues present in non pathogenic E. coli K-12 strains [10], [13], [14], [15], this is not the case for ibeA [11], [16], which has originally been identified in archetypical NMEC strain RS218 (O18 K1 H7; ST95) through a TnphoA mutagenesis approach [12].

TLR4 has originally been identified as an innate sensor of LPSs, components of the cell walls of Gram-negative bacteria.

The gene SASH1 (SAM- and SH3-domain containing 1) has originally been identified as a candidate tumour suppressor gene in breast cancer.

KLEIP has originally been identified as a hypoxia-inducible protein in vitro that regulates the stability and transcriptional activity of Hif-2α, which suggested a functional relationship between KLEIP and Hif-2α (Higashimura et al., 2011; Nacak et al., 2007).

An interesting point is that the RIRE1 element has originally been identified in O. australiensis, a wild relative of rice [ 51], where its 30,000 copies represent 27%% of the host genome.

Elvis had originally been identified as a reasonable ballad singer.

It was considerably more stable than the best variant from a previous Proside selection, in which positions were randomized that had originally been identified by computational design.

The wingless gene had originally been identified as a recessive mutation affecting wing and haltere development in Drosophila melanogaster.

ErbB4 is the only ErbB family member that binds all four neuregulins, as well as several proteins that had originally been identified as EGFR ligands (Fig. 1).

Cases in the records had originally been identified through passive case detection using clinical examination and microscopic detection of trypanosomes in blood and CSF [ 8].