Conversely, β-processing to make C2 PrP is thought to be conducive to prion replication and while in vivo cleavage of APP by β-secretase, BACE1, is well understood, this is not the case for C2 PrP, where facilitated cleavage has only been produced in vitro (McMahon et al, 2001; Watt et al, 2005).
Tesla has only been producing cars for about a decade and we're up against massive, entrenched competitors.
Although he has only been producing for a relatively brief period of time, his music is full of purpose and true to itself.
The actuaries' projections are the gold standard -- not CBO, which has only been producing projections of Social Security's long range for just a little more than a decade and lacks the necessary actuarial expertise.¹.
When he ran along the Nou Camp touchline after the extraordinary defeat of Bayern Munich, one which could have only been produced by a team of quite extraordinary motivation, it was the rejoicing not so much of a battle-hardened warrior but someone who would never lose a part of his youth.
Until now, tapered ZnO nanowires have only been produced by chemical synthesis or electrochemical deposition method [11].
So far, scFv-based N-terminal trimerbodies have only been produced in eukaryotic systems (Sánchez-Arevalo Lobo et al. 2006; Blanco-Toribio et al. 2014).
Containing 98% silica, the principal ingredient of glass, it could have only been produced by one of two processes: Either its constituent minerals crystallized from hot springs, or it formed from the residue of fumaroles, steamy caustic volcanic vents.
Originally The Tales of Beedle the Bard had only been produced in a limited number of seven handmade copies, all handwritten and illustrated by the author herself.
