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The era of the stock-market bubble has now well and truly ended.
The controversy surrounding the original protection of a place like Brou beach has now well and truly passed.
Winter has now well and truly arrived and with it the attendant nightmares, the sense that things can only get worse before the promise of bittersweet spring.
The stock market bubble has now well and truly popped and the rebalancing of the economy away from over-investment has not yet begun.
Following Liverpool's dismal defeat at St James' Park on Sunday, however, it is hard to escape the feeling that the 23-year-old has now well and truly headed down a dark tunnel that can lead only to him being remembered by Kopites with a shake of the head and an almighty sigh.
Prime has now well and truly arrived.
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Keira Knightley, Gemma Arterton, Carey Mulligan, Emily Blunt, Claire Foy... there's a whole generation of British screen actresses who have now well and truly come of age, safely launched into what could well be the prime of their careers.
The Blues might have started the European campaign with a surprise home defeat to Basel last month, but the scars from that night have now well and truly healed.
Looking at what we have now, well, let's just say we're far, far away from that vision.
Many randomised studies have now well established the role of radiotherapy (RT) in rectal cancer: it decreases the rate of local relapse and improves survival for stage II and III.
It has now moved well over three million copies.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com