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A genetic overlap between type 2 diabetes and depression has been reported in twin studies, but the finding has not been replicated with data from genome-wide association studies.
82– 84 A single pathological study carried out in 4 dystoniatonia brains found perinuclear inclusion bodies in midbrain reticular formation and periaqueductal gray matter, 85 but so far this finding has not been replicated, with the remainder of pathological studies not having detected any specific abnormalities.
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Satisfactory reliability has been reported for the measure of pressure pain threshold (PPT) using a hand-held algometer in patients with acute neck pain [ 28], however, this has not been replicated in patients with chronic neck pain.
While the Δ32 deletion variant of C-C chemokine receptor type 5 (CCR5) [ 65] was protective against HAND in pre-cART populations [ 58, 64, 66], this association has not been replicated in individuals with HIV/AIDS diagnosed after 1991, possibly due to reduced impact on viral load in the cART era [ 32, 54, 56].
The CTGF −945 GG genotype was associated with increased susceptibility to systemic sclerosis in a British cohort [ 22], but this finding has not been replicated in other cohorts with systemic sclerosis of North American, Thai and European ancestry [ 32- 34].
This study has not been replicated, however, and was associated with a relatively modest odds ratio, less than expected with homocysteine.
However, this finding has not been replicated in independent patient cohorts with CPEO.
Although the subgroup hypothesis was made a priori and differences are in the anticipated direction, the analysis is based on between group differences, has not been replicated and differences between results with the two devices is easily explained by chance (p=0.22).
However, the association with TOLLIP has not been replicated independently.
The high rate of HCC among human hemochromatosis patients with cirrhosis has not been replicated in animal models of this disease [ 2, 9].
But this approach has not been replicated across the board.
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