Sentence examples for has not been recapitulated from inspiring English sources

Chk1 has been shown to activate Wee1 in Xenopus extracts and yeast; however such a relationship has not been recapitulated in higher eukaryotes [ 18, 19].

In addition, the atypical type 2 PrPSc has not been recapitulated in an experimental transmission of MV2K to PrP-humanized mice carrying the 129M/V genotype [ 13].

The MET cascade has not been recapitulated in tumor progression, however, and the cellular and molecular regulators that promote MET of metastatic tumor cells remain unknown.

Enhanced growth of root systems has been well characterized in field-grown plants; however, this has not been recapitulated in studies of gel-grown Arabidopsis plants.

In contrast, small case series suggested that IBD patients of African descent are at greater risk of PSC, [ 26, 27] although this has not been recapitulated in a larger study [ 28].

The link between cyst development and histone acetylation observed in E. invadens has not been recapitulated in E. histolytica due to lack of an in vitro system for encystation.

However, the activities of the remaining two P450 enzymes have not been recapitulated.

And it is largely true that the ethnic, tribal and religious conflicts that have raged elsewhere in the world have not been recapitulated in this country, where Irish Catholics and Irish Protestants may not adore one another but do live in peace, as do Greeks and Turks, Arabs and Jews, and just about everybody else.

However, data on the first identified substrate, moesin, which is a filamentous actin tether, have not been recapitulated ex or in vivo[ 36].

Disease heterogeneity also presents difficulties in extrapolating preclinical results obtained in small numbers of cell lines or patient xenografts, although limited drug penetration may also explain why encouraging preclinical results from subcutaneous osteosarcoma xenografts have not been recapitulated in subsequent phase I trials.

While the introduction of any single NZM2410-derived locus has not been shown to recapitulate complete disease, the presence of both the Sle1 locus and the Sle3 locus on the B6 background results in severe glomerulonephritis, reinforcing the notion that multiple genetic alterations in several cell types may be necessary to drive lupus pathogenesis [ 28].