Exact(2)
Recent reports indicate that 'filaggrin' has nonsense mutations in ichthyosis vulgaris (IV) patients and is the major predisposing factor for atopic eczema, asthma, and allergies (Smith et al, 2006; Irvine, 2007; Palmer et al, 2006; Sandilands et al, 2009).
The skin barrier phenotype of EPI−/− mice shares similarity with the flaky tail mouse, which has nonsense mutations in the keratin filament associated protein filaggrin and the transmembrane protein Tmem79, which is a component of lamellar granules (Fallon et al., 2009; Sasaki et al., 2013; Saunders et al., 2013), the latter resulting in defective stratum corneum formation.
Similar(58)
Now, you don't succeed all the time, and bureaucrats still exist, and people still have nonsense sessions, budgets.
WE'LL always have nonsense, like Mr. Lott calling his comments a mistake, even though they are utterly in line with a career's worth of words and deeds.
Miszalski and his co-workers have "nonsense conversations" or even "make animal noises" to perk up.
The most resistant cultivar, SHZ-2, had nonsense mutations in two genes (OsGLP8-1 and OsGLP8-11), consistent with lack of detectable transcripts.
To see whether there is any functional bias in genes having nonsense SNPs, we examined the frequent biological terms in the genes having nonsense SNPs.
There is a possibility that the nonsense SNPs detected here have pathological effects, in particular, if non-dispensable genes have nonsense mutations.
Of these, three genes have stop codons, two of which are in transcriptional regulators (FTT1075 and FTT1076), and two genes have nonsense mutations in Schu S4.
On the other hand, the genes having nonsense SNPs predicted to not cause NMD showed less bias in biological function (Table 9).
aux136 [33], [33] and auxF956* [34] have nonsense mutations positioned between the codons for the clathrin binding domain and the J domains, which binds Hsc70.
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