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Sofosbuvir has no significant interaction with most ART including tenofovir, emtricitabine, efavirenz, rilpivirine, and darunavir.
Given that dication 42 has no significant interaction with the electron-rich macrocycle 43, the proposed mechanism is that the thread first reacts with 1,4-bis(bromomethyl benzene to produce a tricationic species containing an electron-deficient bipyridinium motif, which does bind strongly within the cavity of 43 (Scheme 11, intermediate shown in square brackets).
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Here, we have characterised for the first time the biophysical properties of the isolated Josephin motif, showing that it is an autonomously folded unit and that it has no significant interactions with the C-terminal region.
Substantial evidence also show that raltegravir has no significant interactions with other antiretrovirals and concomitant medications and has a good safety and tolerability profile.
Neither VEGF-A nor -B had prognostic significance for OS; they had no significant interaction with the chemotherapy treatment arm.
In this sense, we found that the relationships between Differential WL and DM are not moderated by expected WL (Pre-Task WL), as Differential WL and Pre-Task WL had no significant interaction and presented parallel relationship patterns with DM.
The interaction of two hysteresis rods in a variety of relative geometries are tested; perpendicular rods are found to have no significant interaction while parallel rods could have their dampening ability reduced by half, depending on the rod separation distance.
The matrix approximation approach is based on the concept that most gene pairs in the large-scale genetic interaction screens have no significant interaction with each other, suggesting that the double-mutant fitness matrix W alone should carry enough information for the estimation of the vector w of single-mutant fitness effects under an appropriate null model (see Methods for details).
In contrast, the imine C=N π and π* orbitals have no significant interaction with any orbital on the halogen-bearing A-ring.
This result was in line with a previous study of MDD patients; the severity of depressive symptoms had no significant interaction with increment vMMN in MDD patients [ 24].
Briefly, the matrix approximation strategy is based on the observation that most gene pairs in the large-scale genetic interaction screens have no significant interaction with each other [ 2, 3].
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