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Repeated switching between the reference and biosimilar product may present postmarketing safety surveillance challenges to differentiate adverse events for each product; therefore, data should show that repeated switching from reference product to biosimilar (and vice versa) has no negative effect on the safety and/or effectiveness of the products as a result of immunogenicity.
We perceive that considering proteins belonging to more than one leaf GO term has no negative effect on the GO term predictability.
The intervention is a significant one, but student feedback demonstrates it has no negative effect on the affective atmosphere of the classroom.
Results revealed that, addition of cerium or gallium has no negative effect on bioactivity and hydroxyapatite forming ability of the glass in long term.
For direct associations the correlated measurement error usually has no negative effect on the results, while for indirect associations, depending on the relative size of the correlated measurement error, results can become unreliable.
One of the main conclusions to be drawn from the results presented is that, in the case of base excitation, the transducer's first bending mode has no negative effect on the measurement accuracy.
Similar(29)
The speed of the program is such that it has no negative effects on the system.
Lastly, it has been shown that the hydrogen injection has no negative effects on NO emission but induces a strong increase of CO emission.
Electrochemistry shows that the density multiplication has no negative effects on the Pt utilization of the monolayer arrays, and a remarkable ECSA value of ∼114.5 m2 g−1 is found.
Moreover, MTT assay indicated that the BCP/PVA porous scaffold has no negative effects on cells growth and proliferation, and the hBMSCs possessed a favorable spreading morphology on the BCP/PVA scaffold surface.
Furthermore, Adminsitration of PFC emulsions has been well tolerated by infused animals and has no negative effects on microvascular perfusion [12], [19].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com