Sentence examples for has no functional impact from inspiring English sources

The A299V change is a variant with unknow significance, and further studies are needed to confirm that it has no functional impact.

Also, if this change has functional impact, our subjects (65 and 70 years, both asymptomatic) would be compound-heterozygotes for AIP mutations, whereas AIP knockout mice are not viable (they die at embryonic age e10.5 e14.5 due to cardiac malformations) [ Lin et al., 2007], thus suggesting this change has no functional impact.

On the basis of this annotation, two variants (R693H and W815R) predicted to have a strong functional impact and one variant (N661S) predicted to have no functional impact were chosen.

In this context, there is a great need for new approaches that can distinguish those genomic changes that drive tumor initiation or progression from neutral changes that have been acquired by the clone but have no functional impact.

However, a substantial proportion of differences may have no functional impact on human-specific diseases.

These results strongly indicate that immunoproteasome-mediated changes in proteasome activities have no functional impact on healthy aging of the lung.

It has been argued that proteins containing repeats simply reflect the propensity for variation and that these regions are not subject to selection and have no functional impact [ 43, 44].

Therefore, computational tools are unable to aid in correctly diagnosing mutations found to have no functional impact in the laboratory, even when we used a strict rule for laboratory neutrality where only mutations with no measureable functional effects are given the lab-neutral designation.

Are the truncations in the very distal portion of the Novex-3 exon seen in robust old age because they have no functional impact at all (i.e. normal levels of both full-length and Novex-3 message and protein due to avoidance of NMD in both)?

Variant alleles in indirect association usually have no functional biological impact, and are often encoded as 1 or 0 to indicate the presence or absence of a particular allele.

Thus, there is no reason to believe that the FTO rs9939609 A-allele has any functional impact on leptin in addition to the effect on fatness.