5-FU is an S-phase-active anticancer agent, and it has no activity when cells are in G0 or G1[3].
Dextro-naltrexone is a stereoisomer of naltrexone which is active at microglia receptors but has no activity on opioid receptors [ 26].
Conversely, rifampicin activates the human and rabbit PXR but has no activity on the mouse or rat receptors [ 3].
Enterocin RM6 is active against all tested Gram-positive bacteria, but it has no activity against Gram-negative bacteria (Table 2).
Surprisingly, the full-length GPSLAT-2 receptor chimera rescues the fertilization defect of lat-1 ok1465) lat-1 ok1465has no activity in tissue polarity signaling, a profile indistinguishable fromutantsructs lacking an active 7TM domain.
Strictly speaking, this protein has no activity modulation but the compounds are nonetheless "mapped" in the binding sense.
It has activity against KPC-type carbapenemases and some OXA enzymes; however, it has no activity against metallo-β-lactamases (such as NDM-1) [78].
FLAP was molecularly identified via a photoaffinity probe and an affinity gel based on MK-886, a selective leukotriene inhibitor that has no activity against broken-cell preparations of 5-LO.
These results are in favour of the sequential BH4− hydrolysis (yielding H2) followed by hydrogen oxidation reaction (HOR), or direct sequential BOR on Pt/C, whereas Ag/C promotes direct but incomplete BOR (Ag has no activity regarding hydrogen evolution reaction, HER).
The enzyme retains approximately 10% of the steady state oxidase activity using the artificial electron donor TMPD, but has no activity using the physiological electron donor cytochrome c4, since the docking site for this cytochrome is presumably located on the absent domain of CcoP.
BtsIA alone has no activity unless it mixes with BtsIB to reconstitute the BtsI activity.
