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Kim Alexander, president of the nonpartisan California Voter Foundation, said that although the ballot often has multiple measures dealing with the same issues, this case is peculiar.
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Since a number of subjects did not have multiple measures, this reduced the sample size and made comparisons of the risk of retinopathy between the primary analyses and the secondary analyses difficult.
Nine studies had multiple measures.
However, there is additional utility in having multiple measures across gestation.
Thus, it would be useful to have multiple measures of both reading skill and print exposure.
A study could have multiple measures and each measure could independently have a positive, neutral or negative impact.
For markers with good reproducibility within subject, having multiple measures may provide additional information about the relationship between exposure and disease, if the relationship does vary across time.
GEE estimates the population averaged model while accounting for the correlation among observations as a result of having multiple measures from the same person over time.
Of the remaining 411 patients eligible for follow-up, 355 (86%) had multiple measures (median = 5) of serum cystatin C to estimate GFR and multiple determinations of ACR (median = 5) during 4 years of follow-up.
For markers with poor reproducibility within subject, having multiple measures of exposure may give a more accurate representation of average exposure and confer greater power for detecting an association with preterm birth.
Having multiple measures at each of these 180 units strengthens the power of the analysis since the multiple measures that will be used to estimate service users' autonomy, dignity, satisfaction with care, and markers of recovery will have less bias than a single service user measure.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com