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The latter also has modest affinity for propionate [ 32].
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L-SPD also had modest affinity for D2 receptor and serotonergic 5-HT1A receptor.
These inhibitors often have modest affinity for their target (midmicromolar to millimolar) in addition to poor cellular permeability and stability due to their peptidic nature, and these features make them undesirable for use as biological probes or therapeutics.
These derivatives had modest affinity and antagonistic activity for dopamine D2/D3 receptors.
In the present study, we show that although AZD9773 has a modest affinity for TNFα in a binding assay, the K i in a cell-based assay is approximately four orders of magnitude lower.
During our investigations, it became apparent that the neutral antagonists identified so far had all modest affinity for the receptor.
However, BikBH3 also has modest Mcl1 affinity, which may explain its effect at the high concentrations studied (Table 1).
12Y-2, hasever, has only a modest affinity for AMA-1 in the order of 358 nM (KD) making it an ideal candidate for affinity maturation.
For such a role, it makes sense that a transport-facilitating protein such as JAZ should have quite a modest affinity for the substrate, with no sequence specificity.
L-SPD has been shown to have high affinity for dopamine D1 and modest affinity for D2 receptors and serotonergic 5-HT1A receptor.
Each of the constructs showed modest affinity for immobilized HA.
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