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The in vitro RNA binding assays and point mutagenesis data suggest that Gadd45a has moderate affinity for nonspecific RNAs and high affinity for specific RNAs.
It has moderate affinity for H2 receptors.
Olanzapine also has moderate affinity for the α-adrenergic1 receptor.
It also has moderate affinity for D4, 5HT2C, 5HT7, and alfa1-adrenergic and histamine (H1) receptors (Shapiro et al. 2003).
Because Vps33 has moderate affinity for vacuole SNARE complex, it was also possible to assess the temperature sensitivity of SNARE complex Vps33 binding without Sec17.
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Usually, they primarily have high affinity for somatostatin receptor subtype 2 (sst2), and they have moderate affinity for sst5.
In addition, although protein A and protein G have strong binding affinity for human IgGs, protein G has moderate affinity and protein A has weak affinity for mouse IgGs commonly used in research.
AF150(S) has moderate affinity with an apparent equilibrium dissociation constant for high-affinity binding sites, K d,H = 200 nM for M1ACh-R in rat cerebral cortex and shows functional selectivity for M1ACh-R in transfected cells [25].
The localization of EerI to the ER membrane by the aromatic domain appears to be responsible for the improved target specificity because replacing this domain with another benzene-containing moiety that has a moderate affinity for the ER membrane produces a compound that has activities closely resembling EerI.
Unlike fluvoxamine, sertraline, which has a moderate affinity for sigma-1 receptors, did not alter NGF-induced neurite outgrowth.
While the short targeting peptide has only moderate affinity for the target receptor it does not appear to induce blocking antibodies, so it should be useful in multiple dosing strategies or for multiple vaccines.
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