As urethane has mild effects to individual receptor systems, and coupling between electrophysiologic activity and hemodynamic response is maintained, this anesthetic may also be suitable for other phMRI studies.
H2 also has mild effects without interfering with biological cell signaling, which is different from some conventional antioxidants [ 125, 128].
In diabetic mice and in lupus-prone MRL/ lpr mice, the blockade of CD80 worsens the severity of both diseases, whereas blockade of CD86 prevents diabetes and has mild effects on lupus [ 31, 32].
These results suggest that GO2KA1 has milder effect on SI activity, when compared to acarbose.
Temperature and SO2 concentration had mild effects on the initial conversion rate and negligible effects on the ultimate conversion.
Thus the shuttle cysteine mutations had no obvious effect on Erv1 localization, which is consistent with the observations that shuttle cysteine mutants had mild effects on the in vitro import of Erv1 [ 23, 39].
While B cell depletion has benefited a number of SLE patients, a clinical trial on B cell depletion therapy has yielded negative results and some biologics such as anti-Blys therapy have had mild effects.
Five variants are predicted to have mild effects: K111E (not conserved), R147W and R199P (no effect in Y. lipolytica), and P252R and R257Q (no complex I in Y. lipolytica).
The functional impact of common variation in this region needs to be examined experimentally, but we could speculate that the diversity of coding variants among different ethnicities could have mild effects on the phenotype disparity observed among these populations.
Inhibition of RA signaling by BMS453 treatment completely abolished expression of XPDIp in dorsal pancreas, but had mild effects on the ventral pancreas, suggesting the development of dorsal pancreas is more RA signaling dependent [ 129].
N-Ras-G12V from tumors and N-Ras-G60E from Noonan patients both strongly affected the major:minor axis ratio, whereas N-Ras-T50I only had mild effects (Fig. 3C).
