Estimating the required sample size for a study is necessary during the design phase to ensure that it will have maximal efficiency to answer the primary question of interest.
That is operationally super lean and that has maximal impact on bottom line metrics.
However, the majority of these redundant reactions are preserved because they have differential maximal efficiencies at different conditions or their loss causes an immediate fitness reduction that can only be regained via mutation, drift, and selection in evolution.
The signals produced in the presence of 2 and 3 units per assay were interdispersed, suggesting that maximal efficiency had been reached around this level.
There was no further increase in the initial slope of the 3 Taq-unit group when compared to the initial slope of the 2 Taq-unit group, again suggesting that maximal efficiency had been reached.
Combinatorial therapy using aptamers and siRNA has proved useful for achieving maximal efficiency and efficacy in targeting.
Recently, several consensus statements and guidelines have been issued to achieve maximal efficiency and safety of sedation procedures [ 5, 21].
Two key differences between our study and the commonly used interpretation of CCE are that (i) we demonstrated increase in efficiency but not in complexity and (ii) our task had a well-defined end point representing maximal efficiency (the beeline path) rather than being open-ended.
To achieve the maximal efficiency in energy savings, regulatory mechanisms for protein synthesis have been evolutionarily established at the initiation stage and are regulated by a family of eIFs (47).
The efficiency has a maximum for a finite hammer length (incident wave duration), and the highest maximal efficiency is obtained for a linear FPR.
