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The spread of Isis into south Asia has major ramifications.
Now that superheroes have taken over the summer box office, what happens in comics has major ramifications for mainstream culture.
Mr Obama's decision to keep the US military in Afghanistan beyond his tenure has major ramifications for the 2016 presidential race.
With 44 million households having used the Internet to pay a bill in the past 30 days — up from 32 million five years ago and projected to reach 55 million by 2016 — it's a shift that has major ramifications for competition.
Nevertheless, BAS' solution has major ramifications for the cable-based Internet access business.
This rapid uptake has major ramifications for national electricity infrastructures and requires large investment to cope with short peaks in load.
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This observation may have major ramifications for arsenic-containing groundwater percolating through iron-rich soil.
Such a decision, however, would have major ramifications for the debate over faith-based initiatives.
The Trident vote will also have major ramifications for the Labour party.
Clarkson's departure could have major ramifications for BBC Worldwide's global TV deals.
CEN says the article has had major ramifications for its business.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com