The existence of such trade-offs in multiple phenotypes results in a paradigm where no single mutation can be advantageous for all phenotypes in all environments (Fisher 1930; Levins 1968) and has major implications on rates and limits of adaptation (Orr 2000, 2005).
Most of the phase III trials on AEDs in children have major methodological limitations that considerably limit meaningful conclusions about comparative efficacy between old and new molecules.
But, she said, insurers have "major concerns" about limits on their ability to vary rates according to the ages of subscribers.
That being said, however, previous studies regarding status discordance have two major limits.
He thinks ads, in their current state, have some major limits because of issues with usability and effectiveness.
Although meta-analysis studies are interesting, they have several major limits.
Currently available vaccines have clearly major limits and new vaccines are under developing in order to better control this disease.
These changes in technology have had major pay-offs hardly limited to mapping routes.
The use of this technology would have major implications for, but not limited to, the study of neurological disorders, pathological studies, therapeutic screening, and drug addiction.
13 Most of these factors and also the cost of premiums have a major limiting impact in developing countries, which often have a majority of the population living in abject poverty and are striving under many pressures to achieve universal health care.
