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Although its chemical property is similar to that of natural bone, its limited antibacterial property has made it less desirable for use in present-day clinical applications.
Trichostatin A (TSA) was one of the first HDAC inhibitors to be discovered and although its anti-cancer properties are well documented, its sub-optimal in vivo stability has made it less attractive for use as a chronically administered anti-cancer drug [31], [32].
Still, the nature of German industry -- with its emphasis on highly engineered, capital-intensive products -- has made it less vulnerable to a wholesale transfer of factories to China.
Banks have cut back on lending to small businesses as regulation has made it less lucrative.
But far from making nation-states redundant, it has made it less risky to seek nationhood.
Further, he added, the program's importance for book sales has made it less lively.
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The chief executive of Thorntons has said the recent heatwave has not been good for chocolate sales but claimed its new strategy had made it less vulnerable to the vagaries of the weather.
First Niagara's management has much commercial banking experience, he said, and its earnings from high-yielding business loans have made it less vulnerable to interest rate shifts.
Lower natural-gas prices have made it less competitive.
The deepening liquidity problems at the company have made it less attractive to investors.
Paradoxically, the very things that made the stimulus more effective economically may have made it less popular politically.
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