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Although MCo-TSP-1 has lower stability than SFTI-TSP-1, more than 50% of both peptides remained in human serum over a 24-h period.
The strands are separated, allowing the single-stranded mature microRNA whose 5'end has lower stability base pairings, to associate with the RNA-induced silencing complex (RISC), while the other strand is degraded.
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Patients with poorly controlled diabetes have lower stability at the first 2 to 6 weeks.
32 42 4 months Patients with poorly controlled HbA1c have lower stability in the first 2 6 weeks, but it reaches the baseline in the following weeks.
Thermal and chemical denaturation studies on these mutant thioredoxins showed that three of the four dimeric mutants had similar stability to wild-type thioredoxin while one had lower stability.
Although anchored complexes demonstrated positive properties compared with homogeneous analogs (the raise in catalytic activity and the number of catalytic cycles, selectivity) [6, 7], however, they had lower stability after increasing the temperature of the reaction.
For the first time we have characterized a functionally efficient wild-type p53 from buffalo having lower stability than human p53 and thus, buffalo p53 could be used as a model system for further insight to the molecular basis of wild-type p53 instability.
It is no surprise that non-coding regions have lower stability than protein-coding regions.
Furthermore, through the analysis of minimum free energy, our result agreed with previous report that lincRNA have lower stability than protein-coding RNA.
The result showed that the miRNAs that respond to EFs have lower stability (Supplementary Figure S2), which suggests that miRNAs with rapid turnover more likely tend to implicate in the response to EFs in the MCF-7 cell.
These results suggest that while the Δ5KA maintains similar secondary structure to the WT, it has lower molecular stability, perhaps as a result of five K-to-A mutations.
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