Sentence examples for has low affinity for from inspiring English sources
Most cells are selectively adhered on micro-structured silica particles, while a flat surface has low affinity for the cells.
This inhibitor has low affinity for human renin yet binds very tightly to the yeast proteinase (Ki=4 nM).
Methicillin resistance in Staphylococcus and Macrococcus is due to the production of an alternative penicillin-binding protein (PBP2a, also called PBP2′ or MecA, MecB, and MecC) that has low affinity for almost all β-lactams13,14 β-lactams13,14
To investigate cellular consequences of altering class II/CLIP affinity, we evaluated invariant chain (Ii) mutants with varying CLIP affinity for a mouse class II allele, I-E(d), which has low affinity for wild-type CLIP and is associated with a mouse model of spontaneous, autoimmune joint inflammation.
GDH has low affinity for ammonia (KM = 1 2 mM) (Sharkey and Engel 2008), while GS has high affinity (KM = 0.1 mM) (van Heeswijk et al. 2013).
However, previous DNA binding studies indicated that IntI1 has low affinity for the double-stranded attC compared to the bsattC and dsattI1 [12] [14].
The bacterial family is subdivided into type I and type II1; type I enzymes are cytosolic, expressed constitutively and have low affinity for L-Asn, resulting in non-therapeutic applications, while type II enzymes are restricted in the periplasmic space, with induced expression during anaerobiosis, have high affinity for L-Asn and present antitumor activity2,3.
Two peptides that have low affinity for a target protein are then linked together to improve the binding affinity of the construct, a well-known technique to create high affinity ligands from two low affinity ligands [15], [16], [17], [18], [19].
Others working on assessing performance of prediction methods in the yeast model organism have previously hypothesized that conservation-based methods might be more sensitive than PWM scanning and better at detecting motifs of binding sites that have low affinity for the transcription factor [14].
Values indicate that R31 had low affinity for carbonaceous substrate as well as for ammonia.
