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Thus the safety evaluation of biopharmaceuticals and plasma derivatives in animals has limitations that cannot be adequately addressed by the use of testing paradigms used for small molecule pharmaceuticals.
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While the survival advantage of early and aggressive FFP transfusion in early formula-driven resuscitation cannot be ignored, the evidence behind it has limitations that are discussed next.
Observational studies of HT use in breast cancer survivors have design limitations that cannot be controlled for using standard statistical methods.
Observational studies of HT use in breast cancer survivors have design limitations that cannot be controlled for using standard statistical methods and hence should be considered essentially uninformative with respect to the safety of HT use in breast cancer survivors.
For those limitations that cannot be remedied, data sources, assumptions, and limitations should be documented.
Family caregivers realized that they, too, are vulnerable and have limitations; that they are not in control and cannot fix things on their own.
But, like other observational studies, this study has limitations including its cross-sectional nature that cannot establish causal inferences.
Other missed links were births that occurred outside Scotland: thus the process has limitations when it involves a mobile population that cannot be followed up by the administrative database.
However, these techniques usually require multistep sample preparations (hydrolysis and derivatization), instrumental modification, or special equipment, and have limitations, in that most of these methods cannot assign the double bond positions with accuracy and efficiency.
Obviously, our empirical approach might have limitations, insofar one cannot ensure that all the sources of local dynamics are successfully differentiated away.
The h-I estimates had limitations and we cannot rule out that these limitations might be able to explain the absence of clear and independent prognostic values [7] [10], [16] [17], [ 25].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com