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Simply put, declining attendances has led to diminished on-track betting revenue (handles), which in turn has led to smaller purses and reduced income for the horsemen involved.
The fourth evidence-based treatment, the tricyclic antidepressant imipramine, is cardiotoxic when overdosed, which has led to diminished use.
The structures show that the geometries of the active sites of V203A ADH complexes, in particular the complex with NAD and PFB, are very similar to those for wild-type ADH and raise a serious question about the proposal that an increased ground-state DAD for hydrogen transfer has led to diminished hydrogen tunneling for the V203A enzyme.
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It absolves extremists and their supporters from responsibility for creating and maintaining this impasse.Mark ShapiroSkokie, IllinoisSpuds you don't likeSIR – The argument that the dieting craze has led to diminishing returns for American potato farmers should send a clear signal to the industry that it is time to take its product in a new direction ("Pass the spuds", March 25th).
However, it seems the intense competition in the gaming space has led to diminishing revenue as monetization potential slipped over the last few months.
The LDS is the leading form of nanoscale drug delivery platform, an avenue in drug research, known as "nanomedicine", that holds the promise to transcend the current paradigm of drug development that has led to diminishing returns.
The report found that the number of new apps in the world's major app stores has now exceeded the demand for these apps, which has led to diminishing returns in revenue and is now beginning to reflect the role of paid content on the Web — that is, that it's become an increasingly less profitable business model over the years.
All this has led to diminishing Israel's democratic principles and its prospect of remaining a Jewish state.
Within their study group of MPFL-deficient knees, they found less activity in the contralateral somatosensory cortical areas, which may have led to diminished somatic sensation against lateral shifts of the patella (Kadowaki et al. 2017).
In Figure 6G, we have simply concluded that defective epithelial expressions of chemokine and cytokine genes may have led to diminished neutrophil recruitment.
If so, this may have led to diminished physical functioning -- directly through abuse related injury, or indirectly as a component of more general abuse related degradation in physical health -- characterized at baseline.
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