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And that has led to a challenge that doctors and patients in the 1980s and early 1990s may not have imagined: the aging HIV patient.
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Had Mr. Boehner forged ahead with a plan that fell flat with his rank and file, it could conceivably have led to a challenge of his leadership position, and it would certainly have undermined confidence among conservatives in his ability to lead the Republicans.
The widespread use of digital images has led to a new challenge in digital image forensics.
This has led to a significant challenge on the utilization of high carbon-containing resource such as coal.
This has led to a real challenge in observing seasonal use of landscapes, which provide essential resources for pastoralists at different times of the year.
This growth has led to a number of challenges in maintaining and developing the site.
But ultra-fast growth has led to a number of challenges, as Lyft has scaled up quickly.
This has led to a number of challenges; energy is no longer affordable and environmental impacts from the wanton exploitation of firewood are widespread.
There is a scarcity of minorities in the Fire Department, an issue that has led to a successful federal lawsuit challenging its testing procedures.
High-Tech, and Hidden The explosion of digital technologies has led to a new set of challenges for designers trying to create comfortable, uncluttered work spaces, particularly for clients whose jobs — or predilections — involve the use of multiple devices.
It also has led to a shift in strategic challenges around the globe.
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