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Recently, the genetic risk [ 5– 8] associated with RA has largely implicated T-cell biological processes, reactivating the interest in this cell type.
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Clinical studies investigating the neuroanatomical and psychopharmacological substrates of impulsivity have largely implicated monoaminergic corticostriatal systems.
Tumor suppressor p53 has been largely implicated in the metabolic remodeling that cancer cells develop during progression, particularly through the regulation of mitochondrial respiration via TIGAR and COXIV of the respiratory chain [ 30].
Ventral frontostriatal regions have largely been implicated both in motivating behaviour towards obtaining desired outcomes or rewards and, subsequently, in the hedonic impact of rewards once obtained.
For instance, RANTES and IL-8 are elevated in plasma of obese individuals [ 31– 33] and have been largely implicated in obesity-related health complications [ 34– 36] as well as in the mechanisms of cancer progression [ 37– 37].
Processes such as cellular ageing, senescence and chondrocyte apoptosis have been largely implicated in the initiation and progression of cartilage degradation, which is characterised by mitochondrial dysfunction and depletion of cellular energy stores.
Despite their lack of protein coding potential, ncRNAs have been largely demonstrated to regulate the majority of biological processes and have also been largely implicated in cardiovascular disorders.
Over 20 years later he was implicated in bombings of Havana hotels.Mr Posada has largely evaded punishment for these crimes.
The United Nations and human rights groups have implicated both sides in war crimes and crimes against humanity committed during a conflict whose divide has largely fallen along ethnic lines, between a mostly Dinka army and predominantly Nuer followers of Machar.
"That has largely evaporated.
He has largely failed.
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