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However, consistent expression of the protein as insoluble inclusion bodies in bacteria host systems has largely hindered HBx manufacturing via economical biosynthesis routes, thereby impeding the development of anti-HBx therapeutic strategies.
For the present, the scant knowledge about the genetic basis for the intracellular lifestyle and molecular pathogenesis of E. tarda infection has largely hindered the development of a practical effective vaccine used for combating fish edwardsiellosis.
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Development of genomic-based SNPs in cotton has largely been hindered by availability of a high-quality reference, which has led to development efforts largely targeting transcriptome-based SNPs or SNPs identified using reduced representation libraries.
Furthermore, the evolution of their highly-modified skull anatomy has been largely hindered by the scarcity of well-preserved cranial remains.
Mr. Shin is so committed to Baroque music that he has largely forsworn performing on the modern piano because he said it hindered his harpsichord technique.
He has largely failed.
"That has largely evaporated.
He has largely succeeded.
The challenge has largely succeeded.
That view has largely disappeared.
Mr. Doonan has largely recovered.
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CEO of Professional Science Editing for Scientists @ prosciediting.com