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Exenatide, one of the GLP-1R agonists and incretin mimetics, bears a 50% amino acid homology to human GLP-1 and it has a longer half-life in vivo, however, has its side effects including weight loss, nausea and vomiting.
As always, helping people has its side effects, and some rescues are necessary because the safety net exists.
Like any medical intervention, each one also has its side effects.
The country also has its side of Victoria Falls for a natural wonder of another kind.
Additionally, the functional group of glutamine in K166Q can interact with the backbone of S126; S188T has its side chain exposed to the solvent and does not interact with other amino acids.
Even more interestingly, because of a different nearby loop conformation, the following residue in ValA, Arg278, has its side chain close to that of DHQS Arg264 and is conserved among EEVSs, suggesting that it may be the functionally equivalent residue.
Similar(53)
Going for hair replacements or hair-pieces is well and good; but it has its side-effects.
In some crystal structures of SA (1SWE), each Ser residue has its side-chain hydroxy group directed towards the biotin N3′ nitrogen, and hydrogen bonds are formed (although the distance in subunits 1 and 4 in 1SWE is at the limit for a hydrogen bond between such atoms, at 3.2 Å).
It has its tragic side.
That it has its inconvenient side.
But, like any social experiment, it has its dark side.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com