Swatch, which made its name with the colorful and fashionable watches it introduced 17 years ago, has also had its setbacks.
Facebook's efforts to connect the developing world to a range of free, selective internet service has had its setbacks in the past few months, including a major government vote to block the service in India and criticism that the service is a form of "digital colonialism".
Yahoo has had its setbacks.
The chicken-raising enterprise has had its setbacks, like when someone broke into her coop and stole her chickens, but Gugu's steely determination kept the business afloat even through difficult times.
The neighborhood has no subway station, and is more than 10 miles from Midtown Manhattan; remoteness has its charms but also its setbacks.
Roche, Europe's fifth-largest drug maker, has had its own setbacks in recent years, including sluggish sales growth and the surprise acquisition of 20percentt of its shares earlier this year by its crosstown rival, Novartis A.G.
On the Microsoft side, the Windows giant has had its own setbacks in music (RIP Zune).
In the off-season, though, the offense had its biggest setback.
Each, though, has had its share of setbacks.
Still, the company, based in South San Francisco, has had its share of setbacks lately.
