To date most implementation research studies aiming to change clinicians' behaviour have involved trials at the exploratory or definitive randomised controlled trials (RCTs) stages of this framework, with few published studies providing evidence of preceding theoretical or modelling research.
This has involved the trial of both established immunosuppressive agents and also the novel so-called biological therapies, with varying degrees of success.
The NHS-funded trial, called the IVAN trial, has involved 610 patients in 23 hospitals.
But in practice, the trial has involved relitigating the numerous ways Sabrina Erdely, the article's author, failed to corroborate Jackie's central story.
Instead of draft picks and free-agent signings, much of the news of professional football this off-season has involved prosecutors, indictments and trials.
One small open label trial has involved intracranial implantation of fibroblasts engineered to produce neurotrophic factors (Tuszynski et al 2005).
This trial has involved a stroke survivor directly in the development of this protocol (JR) and will liaise closely with her for advice and direction throughout the conduct of the trial and in the dissemination process.
To date, most of these trials have involved single-agent interventions but, increasingly, future trials will test therapeutic combinations that are based on a compelling scientific rationale and testable mechanistic hypotheses.
These trials have involved approximately 600 subjects in 47 human trials, 36 of them in the USA [ 11].
The 5FU trials have involved bolus 5FU schedule [ 8] or 24 hour infusion [ 9], with the exception of one trial where 5FU was given by continuous infusion [ 10].
