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Their polymorphism has initially been studied throughout populations of the world to demonstrate the "Out of Africa" hypothesis.
Although carbamylation has initially been studied in the context of uremia, as urea exists in equilibrium with cyanate anions (OCN−) 6, 32, it was recently shown to be effectively mediated by MPO produced by activated neutrophils 3. Therefore, protein carbamylation in vivo may be mainly driven by inflammation.
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Ultrasound-guided facet injections have initially been studied for cervical[ 38] and lumbar[ 39] facets.
Biological activities of oxidized phospholipids have initially been studied using lipid mixtures obtained after oxidation of polyunsaturated phospholipids, e.g. PAPC, PLPC or biological lipid extracts.
For example, the genetic linkage map of the perennial ryegrass mapping population VrnA has initially been used for a QTL study to characterise vernalization response and contained 93 markers spanning 490.4 cM with an average distance between markers of 5 cM [ 2].
Although this genetic data may have initially been produced to study a specific phenotype, the data can potentially be reused in multiple future studies.
The study had initially been overseen by two highly renowned advisors (S. Feig and W. A. Logan).
DARE had initially been included in the preliminary study, but as no guidelines were retrieved (only systematic reviews and meta-analyses), it was subsequently excluded from the main study.
The patients had initially been enrolled in a prospective observational study investigating the prognostic value of endocrine dysfunction in critically ill patients ("PEDCRIP" Study).
Everolimus had initially been evaluated in HCC in phase I and II studies.
However, these studies were based on SNP genotypes that had initially been identified by an ascertainment (or SNP discovery) process.
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