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Moreover, the compound has improved efficacy in a hedgehog/smoothened signaling mouse pharmacodynamic model.
Sapacitabine has improved efficacy over both gemcitabine and cytarabine in xenograft models (Tanaka et al, 1992; Hanaoka et al, 1999).
In addition, clinicians will demand to see evidence that the combination is likely to be safe and has improved efficacy.
Thus, it is unclear if the combination of HER2 and VEGF inhibition has improved efficacy in the treatment of HER2+ breast cancer.
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Taxane and antimetabolite doublets have improved efficacy compared with single agents.
Pharmacokinetic (PK) parameters like C2h have improved efficacy of immunosuppressive therapy.
Lenalidomide is a thalidomide analogue, designed to have improved efficacy and tolerability over the parent drug.
The 2D contribution maps with fragment information will be useful for the design of novel CCR2 antagonists having improved efficacy.
Because AMG 416 is administered by the IV route, it is anticipated that it may have improved efficacy and superior compliance compared with cinacalcet in this indication [ 16].
At BP 3.75%, the combination was designed to have improved efficacy over the clindamycin BP 2.5%, with increased tolerability over the clindamycin BP 5% combination.
This study aims to identify and characterise new microtubule disruptors, which may have improved efficacy relative to the taxanes in hormone-independent cancer.
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