Despite the fact that in vitro studies are characterized by simple methodology, this experimental model has important limiting factors, related mainly to the bioavailability and cell biodistribution of anticancer drugs.
We have discovered that both planning based upon technical rationality and on political rationality have important limits.
Undoubtedly, association studies have important limits in defining new disease genes.
Although such models have important limits, they represent a substantial technical advance.
All the considered studies have important limits which should not be underestimated, linked to the in vitro artificial and experimental conditions.
Of course, experimental and quasi-experimental evaluation have important limits, in terms of practicality, ethical limits, and the ability to isolate single causal mechanisms in the context of 'open' systems [ 75].
Randomized trials (RCT) are very difficult in this context for ethical and organizational reasons [ 15], and, observational studies have important limits due to the identification of a proper control population and to the type of intervention to be evaluated.
Dr Michael Bonsall, reader in zoology at the University of Oxford, described the research as "super cool work" and said: "This has important implications for limiting the spread of malaria".
"This has important implications for limiting the spread of malaria," Dr Bonsall said, though he also noted that it was "a long way from being deployed".
Each of these valuable datasets, while useful for certain research questions, has important characteristics that limit its application to other questions.
