Some scientists, like Dr. Warren M. Gold, a pulmonologist who is a professor of medicine at the University of California at San Francisco, said the experiment had important flaws in its design.
Re "Annuities and the Puzzle of Income" (Economic View, June 5), in which Richard H. Thaler described some advantages of buying annuities: Annuities are superficially attractive, but they have important flaws the column did not discuss.
Thus, it is possible that studies at low risk of bias have important flaws with respect to methodology and/or reporting (and vice versa), and it is possible that using other scales to assess study quality could have led to different results.
Importantly, most trials have important methodological flaws and have used inconsistent methods and therapeutic endpoints [29].
Importantly, most trials have important methodological flaws and have used inconsistent methods and therapeutic endpoints [ 29].
Previous meta-analyses of randomized clinical trials 10 21 found a non-significant or borderline significant effect of regional anesthesia in reducing short term mortality among patients undergoing hip fracture surgery; however, all included trials had important methodological flaws.
17 18 19 20 For hip fracture surgery, two meta-analyses of 15 and 22 randomized clinical trials comparing regional with general anesthesia found borderline significant results of a reduced short term risk of mortality associated with regional anesthesia, but no evidence of a decreased risk at three months post-surgery or beyond 10 21; all included studies had important methodological flaws.
However, these three studies had significant flaws.
The findings of this computational study have important implications for designing flaw-tolerant nanocomposite systems.
An audacious global plan to stop future influenza pandemics in their tracks adopted by the World Health Organization (WHO) last month--may have an important flaw, researchers say in a new paper.
Craig Gurian, the Anti-Discrimination Center's executive director, said Mr. Johnson had pointed out important flaws in the county's plan.
